When is 2000 bc

Weapons and tools are fashioned from wood, stone, and bone. Cordage, netting, and basketry develop and fiber-tempered pottery is eventually fired. The practice of placing significant burials beneath earth-and-stone mounds is initiated.

American Archaic cultures are those that occur between Paleoindian hunter groups and the peoples who have realized some combination of pottery making, burial mound construction, and garden technology.

The combination varies from area to area. Indian Knoll and other shell-mound sites along the Green River, in Kentucky, begin to be occupied. Lovelock Cave, an open rockshelter in western Nevada, is inhabited, and remains in use until historic times. Spearheads, swords, and imported jewelry appear in European tombs, as do pins with wheel-shaped heads, which may refer to the chariot, a powerful status symbol.

Throughout Europe, small groups seek status by controlling metals and other resources and acquiring the outward signs of wealth. Metalworking, already known in Europe for over a thousand years, increases dramatically.

Smiths handle larger quantities of bronze and gold and exploit sophisticated techniques such as lost-wax casting and casting in molds in many pieces. A shift in funerary practice begins. In place of inhumation burial, cremation becomes the norm; the ashes are interred, usually with a few grave goods, in urns placed in cemetery grounds.

The change seems to indicate new religious concepts, which hold the materiality of the body less important and leave precious objects largely to the living.

The Metropolitan Museum of Art. Western and Central Europe, — B. Bronze Age cultures, ca. Beaker culture, ca. At the same time a critical review of the natural history of breast cancer and the results of current treatments suggest logical inconsistencies in the model. I have therefore constructed a novel paradigm which better fits the available information by suggesting that metastases are not only a result of cellular transmission of breast cancer but sub-cellular transmission using the mechanism of in vivo transfection.

Although this may sound far fetched, there are a series of remarkable studies in the literature which supports this conceptual revolution.