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This study was financed with institutional funds and was approved by the Institutional Review Board at Washington University in St. Conflicts of Interest: Conflicts of Interest: None declared. National Center for Biotechnology Information , U.

J Med Internet Res. Published online Dec 6. Louis, Campus Box , S. Euclid Ave. Author information Article notes Copyright and License information Disclaimer. Corresponding author. This article has been cited by other articles in PMC. Abstract Background Many prescription drugs are freely available for purchase on the Internet without a legitimate prescription from a physician. Objective This study focused on the motivations for using no-prescription online pharmacies NPOPs to purchase prescription drugs rather than using the traditional doctor-patient-pharmacy model.

Methods We selected tramadol as a representative drug to address our objective because it is widely prescribed as an unscheduled opioid analgesic and can easily be purchased from NPOPs. Results Respondents in both groups were primarily white, female, and in their mid-forties nontraditional users to upper forties traditional users.

Keywords: prescription drugs, health care quality, access, evaluation, health policy, substance-related disorders. Methods Selection of Target Drug Since most online pharmacies offer dozens of drugs for purchase, we needed to narrow the focus to users of a single representative target drug. Recruitment It has been widely documented that recruiting and administering surveys over the Internet is an acceptable and beneficial research methodology [ 45 - 46 ].

Survey Instrument Since this study represents a preliminary approach into this area of research, no standardized instruments could address all points of inquiry. Data Analysis A total of tramadol users qualified for and completed this study. Results Demographics As shown in Table 1 , both traditional and nontraditional users were primarily white and female. Table 1 Demographics and health information for traditional and nontraditional users. Open in a separate window. Figure 1.

Tramadol Use Table 2 shows that nontraditional users were more likely to take the higher dose mg traditional users. Table 2 Tramadol use among traditional and nontraditional users. Figure 2. Physical Dependence Both groups had high rates of suddenly stopping their use of tramadol, but nontraditional users were significantly more likely to cease use abruptly traditional users: Figure 3.

Discussion Our data indicate that those who eschew the typical doctor-patient relationship to obtain tramadol through NPOPs do so primarily for reasons related to cost and accessibility and, most importantly, expose themselves to great health risks.

Limitations Inherent in this study are all of the limitations typical of epidemiological and survey research, most notably generalizability and veracity of information gathered. Conclusion Our data suggest that online pharmacies may have a role in supplying prescribed medications because they are convenient and may charge less than traditional brick-and-mortar pharmacies. Acknowledgments This study was financed with institutional funds and was approved by the Institutional Review Board at Washington University in St.

References 1. Quality of global e-pharmacies: can we safeguard consumers? Eur J Clin Pharmacol. Controversies and legal issues of prescribing and dispensing medications using the Internet.

Mayo Clin Proc. Henney JE. Montoya ID, Jano E. Online pharmacies: safety and regulatory considerations. Int J Health Serv. Weiss AM. Buying prescription drugs on the internet: promises and pitfalls. Cleve Clin J Med. Jul, []. Apr, []. Source of drugs for prescription opioid analgesic abusers: a role for the Internet? Pain Med. Quality of online pharmacies and websites selling prescription drugs: a systematic review.

Pharmacoepidemiol Drug Saf. C The Partnership at Drugfree. Marketing and pricing strategies of online pharmacies. Health Policy. Forman RF. Availability of opioids on the Internet. The Internet as a source of drugs of abuse. Curr Psychiatry Rep. Interim final rule with request for comments.

Fed Regist. Prescription drugs purchased through the internet: who are the end users? Drug Alcohol Depend. Prescription opioid abuse among enrollees into methadone maintenance treatment. Impact of Internet pharmacy regulation on opioid analgesic availability.

J Stud Alcohol Drugs. Jun, []. Jones MJ. Internet-based prescription of sildenafil: a patient series. May, [].

Jul 22, []. Castronova JR. Operation cyber chase and other agency efforts to control internet drug trafficking. The "virtual" enforcement initiative is virtually useless. J Leg Med. Feb 16, []. Yahoo News Yahoo News. Jun 11, []. Silverman E. Washington Post. Oct 3, []. Jun 20, []. Jun 17, []. Comparison of simvastatin tablets from the US and international markets obtained via the Internet. Unauthorized medication intake can lead to serious and devastating consequences.

At the time of therapy with Tramadol, you should refuse from driving a car and performing the work that requires high concentration. Tramadol is an opioid agonist; therefore, it can cause mental and physical dependence.

The International Convention classifies this drug as narcotic. The drug is prescribed for elimination of severe and moderate pain syndrome. It relieves symptoms of various etymologies. Most often, Tramadol is used in the following clinical situations:. Patients with traumatic brain injury, high intracranial pressure and epilepsy must take the drug with caution. Under the influence of anesthesia, Tramadol can only be administered under the supervision of a doctor and in reduced doses.

It is forbidden to drink alcohol during the treatment with Tramadol. There are several medicinal forms of the drug. Each of them has its features of admission.

Drops for oral use can be prescribed to the patients over the age of Neuropathic pain arises spontaneously or regularly from damaged nerves.

The neural signals behind neuropathic pain are unlike those channeled from damaged tissue which can appear as the result of a fall, a cut or a burn along healthy nerves. This type of pain requires special medications known as painkillers; it not infrequently ensues from spinal cord injuries, amputated limbs phantom pains and postherpetic conditions.

Opioid painkillers, such as Tramadol and morphine, often come in handy for neuropathic cases. This latter type includes musculoskeletal and visceral pain cases. Sometimes, sources of noxious pain can be localized such as joint pain or cutaneous injuries ; in other cases, the pain may be referred to organs or internal tissues. Antiepileptic and tricyclic antidepressant drugs find common use in the management of neuropathic pain.

Their precise mechanism of action, nevertheless, remains unknown. Initially, neuropathic pain was considered refractory to opioids. It was only recently that opioids were rediscovered as a possible treatment for neuropathies.



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